منابع مشابه
Evolution of the let-7 microRNA Family
The increase of bodyplan complexity in early bilaterian evolution is correlates with the advent and diversification of microRNAs. These small RNAs guide animal development by regulating temporal transitions in gene expression involved in cell fate choices and transitions between pluripotency and differentiation. One of the two known microRNAs whose origins date back before the bilaterian ancest...
متن کاملThe primary target of let-7 microRNA.
The let-7 miRNA (microRNA) is an essential regulator of development from nematode worms to humans. Altered expression of let-7 results in larval arrest or lethality in Caenorhabditis elegans. Likewise, under- or over-expression of let-7 in human cells can result in cellular overproliferation or halted cell division respectively. Thus the biogenesis of this critical miRNA is controlled at multip...
متن کاملMicroRNA let-7 in the spotlight: Role in innate immunity
Innate immunity forms the first line of host defense. It is quick and usually shapes the adaptive immune responses which clear off the pathogens. However, dysregulated innate immune responses can lead to excessive inflammation which causes significant damage to the host. As a result, innate immune responses are tightly regulated. In this review, we focus on mechanisms by which microRNA let-7 re...
متن کاملRAS Oncogene in Brain Tumors, Let-7 MicroRNA Involvement
RAS oncogenes are master regulators of cancers. Somatic mutation in KRAS, HRAS and NRAS genes account for approximately 30% of human cancers. KRAS is the most frequently mutated isoform in RAS-driven cancers. Brain cancers are RAS-driven cancers despite have no RAS mutation or amplification and its pivotal role in brain tumorigenesis has been well documented. Indeed, it’s generally accepted tha...
متن کاملRole of Microrna Let-7 in Pancreatic Beta Cells
............................................................................................................................... vi
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Aging
سال: 2019
ISSN: 1945-4589
DOI: 10.18632/aging.101968